Inflammation and Non-Atherosclerotic Coronary Artery Aneurysm

@Copyright 2014 by Koşuyolu Heart Journal Available on-line at www.kosuyolukalpdergisi.com E-mail: [email protected] Submitted : 03.11.2013 Accepted : 30.11.2013 Mete Gürsoy Correspondence Introduction: Coronary artery aneurysm is generally presented as an asymptomatic, incidental angiographic finding and is often associated with atherosclerosis. In this study we investigated the relation of non-atherosclerotic isolated coronary artery aneurysm with inflammation. Patients and Methods: Data of 6845 coronary angiography were retrospectively evaluated. A total of 35 nonatherosclerotic isolated coronary artery aneurysms were diagnosed in 23 patients (0.34%). Patients follow-up charts were reviewed, demographic and hematologic parameters were determined and were compared with the results of 23 healthy subjects. Results: Neutrophil to lymphocyte ratio was 2.44±0.88 in group I and 1.80±0.49 in group II, and the difference was found to be significant (p=0.01). Serum uric acid level was 6.37±1.80 mg/dL in group I and 4.91±0.99 in group II, and the difference was significant (p=0.008). Conclusion: Present study indicates two important triggering factors in the pathogenesis of isolated coronary artery aneurysm; inflammation and oxidative stress. Antiinflammatory and antioxidant treatments may be a new approach in patients with coronary artery aneurysm.